| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol. Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway. Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane.the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. |
| Protein Name | Voltage-Dependent Anion-Selective Channel Protein 2Vdac-2Hvdac2Outer Mitochondrial Membrane Protein Porin 2 |
| Database Links | Reactome: R-HSA-5205685Reactome: R-HSA-5689880Reactome: R-HSA-8949215 |
| Cellular Localisation | Mitochondrion Outer MembraneMembraneMay Localize To Non-Mitochondrial Membranes |
| Alternative Protein Names | Voltage-Dependent Anion-Selective Channel Protein 2 proteinVdac-2 proteinHvdac2 proteinOuter Mitochondrial Membrane Protein Porin 2 proteinVDAC2 protein |
Information sourced from Uniprot.org
