Human VCAM-1/CD106 (Vascular Cell Adhesion Protein 1) Antibody Pair (STJAP00426)

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STJAP00426-50
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Host: Mouse/Mouse
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This VCAM-1/CD106 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.
Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5.
Purification: Capture Purification: Protein A or G.
Detection Purification: Protein A or G.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Determination Method: Colormetric
Gene Symbol: VCAM1
Gene ID: 7412
Uniprot ID: VCAM1_HUMAN
Immunogen: Capture immunogen: Recombinant Human VCAM-1/CD106 protien.
Detection Immunogen: Recombinant Human VCAM-1/CD106 protien.
Sample Type: Serum, plasma and other biological fluids
Post Translational Modifications Cleaved by the metalloproteinase ADAM17 to generate the soluble form. Sialoglycoprotein. Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination.leading to proteasomal degradation.
Function Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.
Protein Name Vascular Cell Adhesion Protein 1
V-Cam 1
Vcam-1
Incam-100
Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-216083
Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Cellular Localisation Vascular Cell Adhesion Protein 1: Cell Membrane
Single-Pass Type I Membrane Protein
Soluble Vascular Cell Adhesion Molecule-1: Secreted
Alternative Antibody Pair Names Vascular Cell Adhesion Protein 1 antibody pair
V-Cam 1 antibody pair
Vcam-1 antibody pair
Incam-100 antibody pair
Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1 antibody pair
VCAM1 antibody pair

Information sourced from Uniprot.org

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