Human VAP-A protein (Recombinant) (His-Tag) (STJP016613)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human VAP-A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VAPA |
| Gene ID | 9218 |
| Uniprot ID | VAPA_HUMAN |
| Accession Number | NP_919415 |
| Immunogen | Human |
| Immunogen Region | 1-227aa |
| Immunogen Sequence | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMAS ASGAMAKHEQ ILVLDPPTDL KFKGPFTDVV TTNLKLRNPS DRKVCFKVKT TAPRRYCVRP NSGIIDPGST VTVSVMLQPF DYDPNEKSKH KFMVQTIFAP PNTSDMEAVW KEAKPDELMD SKLRCVFEMP NENDKLNDME PSKAVPLNAS KQDGPMPKPH SVSLNDTETR KLMEECKRLQ GEMMKLSE |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. |
| Protein Name | Vesicle-Associated Membrane Protein-Associated Protein AVamp-AVamp-Associated Protein AVap-A33 Kda Vamp-Associated ProteinVap-33 |
| Database Links | Reactome: R-HSA-1660661Reactome: R-HSA-6798695Reactome: R-HSA-9609523 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinCell MembraneCell JunctionTight JunctionNucleus MembranePresent In The Plasma Membrane And In Intracellular VesiclesTogether With Snare ProteinsMay Also Associate With The CytoskeletonColocalizes With Ocln At The Tight Junction In Polarized Epithelial Cells |
| Alternative Protein Names | Vesicle-Associated Membrane Protein-Associated Protein A proteinVamp-A proteinVamp-Associated Protein A proteinVap-A protein33 Kda Vamp-Associated Protein proteinVap-33 proteinVAPA proteinVAP33 protein |
Information sourced from Uniprot.org