Human VAMP8 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP008233)

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STJP008233
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human VAMP8-N-His-SUMO & C-Strep protein was developed from e. coli and has a target region of N-His-SUMO & C-Strep. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: VAMP8
Gene ID: 8673
Uniprot ID: VAMP8_HUMAN
Immunogen Region: Glu2-Lys75
Immunogen: Homo sapiens (Human)
Post Translational Modifications (Microbial infection) Stearoylated By S.flexneri N-epsilon-fatty acyltransferase IcsB, thereby disrupting the host actin cytoskeleton.
Function SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Also plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism.
Protein Name Vesicle-Associated Membrane Protein 8
Vamp-8
Endobrevin
Edb
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-199992
Reactome: R-HSA-432720
Reactome: R-HSA-432722
Reactome: R-HSA-6798695
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Cellular Localisation Lysosome Membrane
Single-Pass Type Iv Membrane Protein
Early Endosome Membrane
Late Endosome Membrane
Cell Membrane
Zymogen Granule Membrane
Perinuclear Vesicular Structures Of The Early And Late Endosomes
Coated Pits
And Trans-Golgi
Sub-Tight Junctional Domain In Retinal Pigment Epithelium Cells
Midbody Region During Cytokinesis
Lumenal Oriented
Apical Membranes Of Nephric Tubular Cell
Cycles Through The Apical But Not Through The Basolateral Plasma Membrane
Apical Region Of Acinar Cells
In Zymogen Granule Membranes
Alternative Protein Names Vesicle-Associated Membrane Protein 8 protein
Vamp-8 protein
Endobrevin protein
Edb protein
VAMP8 protein

Information sourced from Uniprot.org

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