SDS-PAGE gel showing recombinant human VAMP-1 protein 3µg under reducing conditions Coomassie blue stain

Human VAMP-1 protein (Recombinant) (His-Tag) (STJP019799)

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STJP019799
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Short Description :Recombinant-Human VAMP-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in phosphate-Buffered Saline (pH 7.4) containing 1mM EDTA
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:VAMP1
Gene ID:6843
Uniprot ID:VAMP1_HUMAN
Accession Number:NP_055046
Immunogen:Human
Immunogen Region:1-91aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY W
Tissue Specificity Nervous system, skeletal muscle and adipose tissue.
Post Translational Modifications (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which probably hydrolyzes the 78-Gln-|-Phe-79 bond and inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 61-Arg-|-Leu-62 bond and inhibits neurotransmitter release. BoNT/D has low catalytic activity on this protein due to its sequence. Note that humans are not known to be infected by C.botulinum type D. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which probably hydrolyzes the 60-Gln-|-Lys-61 bond and inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which probably hydrolyzes the 68-Arg-|-Ala-69 bond and inhibits neurotransmitter release. It remains unknown whether BoNT/X is ever produced, or what organisms it targets.
Function Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Protein Name Vesicle-Associated Membrane Protein 1
Vamp-1
Synaptobrevin-1
Database Links Reactome: R-HSA-5250955
Reactome: R-HSA-5250981
Reactome: R-HSA-5250989
Cellular Localisation Isoform 1: Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Single-Pass Type Iv Membrane Protein
Synapse
Synaptosome
Isoform 2: Cytoplasmic Vesicle Membrane
Isoform 3: Mitochondrion Outer Membrane
Alternative Protein Names Vesicle-Associated Membrane Protein 1 protein
Vamp-1 protein
Synaptobrevin-1 protein
VAMP1 protein
SYB1 protein

Information sourced from Uniprot.org

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