| Tissue Specificity | Ubiquitous. Expressed in prostate epithelial cells. Expressed in mammary epithelial cells. Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus. Overexpressed in a number of tumor tissues. |
| Post Translational Modifications | Isoform 2: Ubiquitinated by E3 ubiquitin-protein ligase complex containing FBXO7.leading to proteasomal degradation. |
| Function | Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Isoform 1: Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP. |
| Protein Name | Protein UxtAndrogen Receptor Trapped Clone 27 ProteinArt-27Ubiquitously Expressed Transcript Protein |
| Database Links | Reactome: R-HSA-8953750 |
| Cellular Localisation | Isoform 1: CytoplasmIsoform 2: NucleusCytoplasmNucleusCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PolePredominantly Localizes To The NucleusLocalizes To Spindle Pole During Mitosis |
| Alternative Protein Names | Protein Uxt proteinAndrogen Receptor Trapped Clone 27 Protein proteinArt-27 proteinUbiquitously Expressed Transcript Protein proteinUXT proteinHSPC024 protein |
Information sourced from Uniprot.org
