| Post Translational Modifications | Phosphorylated at Ser-445 by PKB/AKT1 in response to EGF stimulus, promoting its ability deubiquitinate RHEB. Monoubiquitinated by TRIM21. Ubiquitination does not lead to its proteasomal degradation. Autodeubiquitinated. |
| Function | Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. Deubiquitinates HAS2. Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 4Deubiquitinating Enzyme 4Ubiquitin Thioesterase 4Ubiquitin-Specific-Processing Protease 4Ubiquitous Nuclear Protein Homolog |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5689880 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Nucleus And CytoplasmExported To The Cytoplasm In A Crm1-Dependent Manner And Recycled Back To The Nucleus Via The Importin Alpha/Beta Heterodimeric Import ReceptorThe Relative Amounts Found In The Nucleus And Cytoplasm Vary According To The Cell Type |
| Alternative Protein Names | Ubiquitin Carboxyl-Terminal Hydrolase 4 proteinDeubiquitinating Enzyme 4 proteinUbiquitin Thioesterase 4 proteinUbiquitin-Specific-Processing Protease 4 proteinUbiquitous Nuclear Protein Homolog proteinUSP4 proteinUNP proteinUNPH protein |
Information sourced from Uniprot.org
