Human USP33 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP010983)

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STJP010983
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human USP33-N-His-SUMO & C-Strep protein was developed from e. coli and has a target region of N-His-SUMO & C-Strep. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: USP33
Gene ID: 23032
Uniprot ID: UBP33_HUMAN
Immunogen Region: Arg36-Glu120
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.
Function Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Protein Name Ubiquitin Carboxyl-Terminal Hydrolase 33
Deubiquitinating Enzyme 33
Ubiquitin Thioesterase 33
Ubiquitin-Specific-Processing Protease 33
Vhl-Interacting Deubiquitinating Enzyme 1
Hvdu1
Database Links Reactome: R-HSA-5689880
Reactome: R-HSA-9010553
Cellular Localisation Cytoplasm
Perinuclear Region
Cytoskeleton
Microtubule Organizing Center
Centrosome
Associates With Centrosomes Predominantly In S And G2 Phases But Less In G1 Phase
Isoform 3: Golgi Apparatus
Alternative Protein Names Ubiquitin Carboxyl-Terminal Hydrolase 33 protein
Deubiquitinating Enzyme 33 protein
Ubiquitin Thioesterase 33 protein
Ubiquitin-Specific-Processing Protease 33 protein
Vhl-Interacting Deubiquitinating Enzyme 1 protein
Hvdu1 protein
USP33 protein
KIAA1097 protein
VDU1 protein

Information sourced from Uniprot.org

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