Human USP30 protein (Recombinant) (N-His) (STJP011022)

SKU:
STJP011022
£328.50 - £1,437.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human USP30-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: USP30
Gene ID: 84749
Uniprot ID: UBP30_HUMAN
Immunogen Region: Gly74-Lys355
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated by parkin (PRKN) at Lys-235 and Lys-289, leading to its degradation.
Function Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
Protein Name Ubiquitin Carboxyl-Terminal Hydrolase 30
Deubiquitinating Enzyme 30
Ubiquitin Thioesterase 30
Ubiquitin-Specific-Processing Protease 30
Ub-Specific Protease 30
Database Links Reactome: R-HSA-5689880
Reactome: R-HSA-9664873
Cellular Localisation Mitochondrion Outer Membrane
Alternative Protein Names Ubiquitin Carboxyl-Terminal Hydrolase 30 protein
Deubiquitinating Enzyme 30 protein
Ubiquitin Thioesterase 30 protein
Ubiquitin-Specific-Processing Protease 30 protein
Ub-Specific Protease 30 protein
USP30 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP005172 Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172) E. coli
STJP004723 Human WAS protein (Recombinant) (N-His) (STJP004723) E. coli
STJP001380 Human TET2 protein (Recombinant) (N-his) (STJP001380) HEK293 cells
STJP007831 Human TFE3 protein (Recombinant) (N-His) (STJP007831) E. coli
STJP007833 Human SLC8A1 protein (Recombinant) (N-His) (STJP007833) E. coli

Related Products

!