| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Supplied as 0.22 Mu m filtered solution in PBS (pH 7.4). |
| Storage Instruction: | Store at-70 °C. This product is stable at ≤-70 °C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | PLAUR |
| Gene ID: | 5329 |
| Uniprot ID: | UPAR_HUMAN |
| Immunogen Region: | Leu23-Gly305 |
| Immunogen: | Recombinant Human uPAR/PLAUR/CD87 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu23-Gly305) of Human uPAR/PLAUR/CD87 (Accession #Q03405-1) fused with a C-hFc tag at the C-terminus. |
| Immunogen Sequence: | LRCMQCKTNGDCRVEECALG QDLCRTTIVRLWEEGEELEL VEKSCTHSEKTNRTLSYRTG LKITSLTEVVCGLDLCNQGN SGRAVTYSRSRYLECISCGS SDMSCERGRHQSLQCRSPEE QCLDVVTHWIQEGEEGRPKD DRHLRGCGYLPGCPGSNGFH NNDTFHFLKCCNTTKCNEGP ILELENLPQNGRQCYSCKGN STHGCSSEETFLIDCRGPMN QCLVATGTHEPKNQSYMVR |
| Tissue Specificity | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
| Function | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. |
| Protein Name | Urokinase Plasminogen Activator Surface ReceptorU-ParUparMonocyte Activation Antigen Mo3Cd Antigen Cd87 |
| Database Links | Reactome: R-HSA-162791Reactome: R-HSA-6798695Reactome: R-HSA-75205 |
| Cellular Localisation | Cell MembraneCell ProjectionInvadopodium MembraneColocalized With Fap (Seprase) Preferentially At The Cell Surface Of Invadopodia Membrane In A Cytoskeleton-Integrin- And Vitronectin-Dependent MannerIsoform 1: Cell MembraneLipid-AnchorGpi-AnchorIsoform 2: Secreted |
| Alternative Protein Names | Urokinase Plasminogen Activator Surface Receptor proteinU-Par proteinUpar proteinMonocyte Activation Antigen Mo3 proteinCd Antigen Cd87 proteinPLAUR proteinMO3 proteinUPAR protein |
Information sourced from Uniprot.org
