Human uPA Receptor/U-PAR (uPA Receptor/U-PAR) Antibody Pair (STJAP00924)
General Information
| Short Description | This uPA Receptor/U-PAR antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R06-9G-1/R03-6P-1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purification |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PLAUR |
| Gene ID | 5329 |
| Uniprot ID | UPAR_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
| Function | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. |
| Protein Name | Urokinase Plasminogen Activator Surface ReceptorU-ParUparMonocyte Activation Antigen Mo3Cd Antigen Cd87 |
| Database Links | Reactome: R-HSA-162791Reactome: R-HSA-6798695Reactome: R-HSA-75205 |
| Cellular Localisation | Cell MembraneCell ProjectionInvadopodium MembraneColocalized With Fap (Seprase) Preferentially At The Cell Surface Of Invadopodia Membrane In A Cytoskeleton-Integrin- And Vitronectin-Dependent MannerIsoform 1: Cell MembraneLipid-AnchorGpi-AnchorIsoform 2: Secreted |
| Alternative Antibody Pair Names | Urokinase Plasminogen Activator Surface Receptor antibody pairU-Par antibody pairUpar antibody pairMonocyte Activation Antigen Mo3 antibody pairCd Antigen Cd87 antibody pairPLAUR antibody pairMO3 antibody pairUPAR antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human uPA Receptor/U-PAR (uPA Receptor/U-PAR) Antibody Pair (STJAP00924)
This antibody pair detects human uPA Receptor (U-PAR), corresponding to UniProt entry Q03405. Reactivity is confirmed for human samples only.
This antibody pair has been validated for use in ELISA. It is intended for research use only and has not been validated for diagnostic or therapeutic applications.
Both antibodies are unconjugated rabbit monoclonal IgGs, purified by affinity chromatography and formulated in 0.01M PBS at pH 7.2. Clone IDs are R06-9G-1 for one antibody and R03-6P-1 for the other.
Optimal working concentrations and dilutions are to be determined by the end user, as no pre-defined dilution range is specified for this product. Titration experiments are recommended to establish appropriate conditions for each laboratory setup.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and keep at -20°C, and avoid repeated freeze/thaw cycles to maintain activity.
Both antibodies in this pair were raised against a recombinant protein immunogen corresponding to human U-PAR. The specific immunogen region is not defined in the product documentation.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.