| Short Description : | Recombinant-Human ULBP-4/RAET1E-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE/Denatured |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 1 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% Glycerol |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAET1E |
| Gene ID: | 135250 |
| Uniprot ID: | RAE1E_HUMAN |
| Accession Number: | NP_631904 |
| Immunogen: | Human |
| Immunogen Region: | 31-225aa |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMHSLCFN FTIKSLSRPG QPWCEAQVFL NKNLFLQYNS DNNMVKPLGL LGKKVYATST WGELTQTLGE VGRDLRMLLC DIKPQIKTSD PSTLQVEMFC QREAERCTGA SWQFATNGEK SLLFDAMNMT WTVINHEASK IKETWKKDRG LEKYFRKLSK GDCDHWLREF LGHWEAMPEP TVSPVNASDI HWSSSSLPD |
| Tissue Specificity | Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid. |
| Function | Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. |
| Protein Name | Retinoic Acid Early Transcript 1eLymphocyte Effector Toxicity Activation LigandNkg2d Ligand 4N2dl-4Nkg2dl4Rae-1-Like Transcript 4Ul16-Binding Protein 4 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinIsoform 4: Secreted |
| Alternative Protein Names | Retinoic Acid Early Transcript 1e proteinLymphocyte Effector Toxicity Activation Ligand proteinNkg2d Ligand 4 proteinN2dl-4 proteinNkg2dl4 proteinRae-1-Like Transcript 4 proteinUl16-Binding Protein 4 proteinRAET1E proteinLETAL proteinN2DL4 proteinULBP4 proteinUNQ1867 proteinPRO4303 protein |
Information sourced from Uniprot.org
