Human UGT1A6 protein (Recombinant) (N-His) (STJP015707)

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STJP015707
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human UGT1A6-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: Please contact us for further information.
Gene Symbol: UGT1A6
Gene ID: 54578
Uniprot ID: UD16_HUMAN
Immunogen Region: Asp27-Asp489
Immunogen: Homo sapiens (Human)
Function Isoform 1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to facilitate their inactivation and excretion from the body. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and 20-HETE. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate. Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group. Isoform 3: Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1.
Protein Name Udp-Glucuronosyltransferase 1a6
Ugt1a6
Phenol-Metabolizing Udp-Glucuronosyltransferase
Udp-Glucuronosyltransferase 1-6
Udpgt 1-6
Ugt1*6
Ugt1-06
Ugt1.6
Udp-Glucuronosyltransferase 1-F
Ugt-1f
Ugt1f
Database Links Reactome: R-HSA-156588
Reactome: R-HSA-9749641
Reactome: R-HSA-9753281
Cellular Localisation Microsome
Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Alternative Protein Names Udp-Glucuronosyltransferase 1a6 protein
Ugt1a6 protein
Phenol-Metabolizing Udp-Glucuronosyltransferase protein
Udp-Glucuronosyltransferase 1-6 protein
Udpgt 1-6 protein
Ugt1*6 protein
Ugt1-06 protein
Ugt1.6 protein
Udp-Glucuronosyltransferase 1-F protein
Ugt-1f protein
Ugt1f protein
UGT1A6 protein
GNT1 protein
UGT1 protein

Information sourced from Uniprot.org

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