| Host: |
E. coli |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human UBE2L3-C-His protein was developed from e. coli and has a target region of C-His. For use in research applications. |
| Formulation: |
Supplied in 50mM HEPES, 200mM NaCl, 10%Glycerol, 1mM TCEP, pH 7.0. Contact us for customized product form or formulation. |
| Endotoxin: |
Please contact us for more information. |
| Gene Symbol: |
UBE2L3 |
| Gene ID: |
7332 |
| Uniprot ID: |
UB2L3_HUMAN |
| Immunogen Region: |
Met1-Asp154 |
| Immunogen: |
Recombinant Human UBE2L3 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Asp154) of human UBE2L3 (Accession #NP_003338.1) fused with a 6×His tag at the C-terminus. |
| Tissue Specificity | Ubiquitous, with highest expression in testis. |
| Post Translational Modifications | Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation. Autoubiquitinated in vitro. |
| Function | Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 L3E2 Ubiquitin-Conjugating Enzyme L3L-UbcUbch7Ubiquitin Carrier Protein L3Ubiquitin-Conjugating Enzyme E2-F1Ubiquitin-Protein Ligase L3 |
| Database Links | Reactome: R-HSA-5357905Reactome: R-HSA-5675482Reactome: R-HSA-8866652Reactome: R-HSA-8866654Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Protein Names | Ubiquitin-Conjugating Enzyme E2 L3 proteinE2 Ubiquitin-Conjugating Enzyme L3 proteinL-Ubc proteinUbch7 proteinUbiquitin Carrier Protein L3 proteinUbiquitin-Conjugating Enzyme E2-F1 proteinUbiquitin-Protein Ligase L3 proteinUBE2L3 proteinUBCE7 proteinUBCH7 protein |
Information sourced from Uniprot.org
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