| Function | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. | 
  | Protein Name | Sumo-Activating Enzyme Subunit 2Anthracycline-Associated Resistance ArxUbiquitin-Like 1-Activating Enzyme E1bUbiquitin-Like Modifier-Activating Enzyme 2 | 
  | Database Links | Reactome: R-HSA-3065676Reactome: R-HSA-3065678 | 
  | Cellular Localisation | CytoplasmNucleusShuttles Between The Cytoplasm And The NucleusSumoylation Is Required Either For Nuclear Translocation Or Nuclear Retention | 
  | Alternative Protein Names | Sumo-Activating Enzyme Subunit 2 proteinAnthracycline-Associated Resistance Arx proteinUbiquitin-Like 1-Activating Enzyme E1b proteinUbiquitin-Like Modifier-Activating Enzyme 2 proteinUBA2 proteinSAE2 proteinUBLE1B proteinHRIHFB2115 protein | 
 
Information sourced from Uniprot.org