Human UBA2/SAE2 protein (Recombinant) (N-His) (STJP009398)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human UBA2/SAE2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | UBA2 |
| Gene ID | 10054 |
| Uniprot ID | SAE2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asp640 |
Additional Info
| Function | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. |
| Protein Name | Sumo-Activating Enzyme Subunit 2Anthracycline-Associated Resistance ArxUbiquitin-Like 1-Activating Enzyme E1bUbiquitin-Like Modifier-Activating Enzyme 2 |
| Database Links | Reactome: R-HSA-3065676Reactome: R-HSA-3065678 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Cytoplasm And The NucleusSumoylation Is Required Either For Nuclear Translocation Or Nuclear Retention |
| Alternative Protein Names | Sumo-Activating Enzyme Subunit 2 proteinAnthracycline-Associated Resistance Arx proteinUbiquitin-Like 1-Activating Enzyme E1b proteinUbiquitin-Like Modifier-Activating Enzyme 2 proteinUBA2 proteinSAE2 proteinUBLE1B proteinHRIHFB2115 protein |
Information sourced from Uniprot.org