Human TYRP1 protein (Recombinant) (C-His) (STJP014433)

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STJP014433-100
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Short Description :Recombinant-Human TYRP1-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications.
Applications:ELISA/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for this information.
Gene Symbol:TYRP1
Gene ID:7306
Uniprot ID:TYRP1_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Gln25-Arg471
Post Translational Modifications Glycosylated.
Function Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.
Protein Name 5 -6-Dihydroxyindole-2-Carboxylic Acid Oxidase
Dhica Oxidase
Catalase B
Glycoprotein 75
Melanoma Antigen Gp75
Tyrosinase-Related Protein 1
Trp
Trp-1
Trp1
Database Links Reactome: R-HSA-5662702
Reactome: R-HSA-9824585
Cellular Localisation Melanosome Membrane
Single-Pass Type I Membrane Protein
Located To Mature Stage Iii And Iv Melanosomes And Apposed Endosomal Tubular Membranes
Transported To Pigmented Melanosomes By The Bloc-1 Complex
Proper Trafficking To Melanosome Is Regulated By Sgsm2
Ankrd27
Rab9a
Rab32 And Rab38
Alternative Protein Names 5 -6-Dihydroxyindole-2-Carboxylic Acid Oxidase protein
Dhica Oxidase protein
Catalase B protein
Glycoprotein 75 protein
Melanoma Antigen Gp75 protein
Tyrosinase-Related Protein 1 protein
Trp protein
Trp-1 protein
Trp1 protein
TYRP1 protein
CAS2 protein
TYRP protein
TYRRP protein

Information sourced from Uniprot.org