Human TYR/Tyrosinase protein (Recombinant) (N-His) (STJP009445)

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STJP009445
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TYR/Tyrosinase-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TYR
Gene ID: 7299
Uniprot ID: TYRO_HUMAN
Immunogen Region: His19-Ser476
Immunogen: Homo sapiens (Human)
Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Protein Name Tyrosinase
Lb24-Ab
Monophenol Monooxygenase
Sk29-Ab
Tumor Rejection Antigen Ab
Database Links Reactome: R-HSA-5662702
Reactome: R-HSA-9824585
Cellular Localisation Melanosome Membrane
Single-Pass Type I Membrane Protein
Melanosome
Proper Trafficking To Melanosome Is Regulated By Sgsm2
Ankrd27
Rab9a
Rab32 And Rab38
Alternative Protein Names Tyrosinase protein
Lb24-Ab protein
Monophenol Monooxygenase protein
Sk29-Ab protein
Tumor Rejection Antigen Ab protein
TYR protein

Information sourced from Uniprot.org

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