Human TSPAN8 protein (Recombinant) (N-GST & C-His) (STJP010880)

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STJP010880
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TSPAN8-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TSPAN8
Gene ID: 7103
Uniprot ID: TSN8_HUMAN
Immunogen Region: Lys110-Asn205
Immunogen: Homo sapiens (Human)
Function Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking. Promotes ADAM17-mediated TNF-alpha processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration. Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR. Contributes to the maintenance of intestinal epithelial barrier and plays a role in the regulation of intestine inflammation by switching interferon gamma receptor 1/IFNGR1 from clathrin-dependent to lipid raft-dependent endocytosis route to limit STAT1 activation magnitude and duration. Acts as a modulator of the endothelin axis by associating with endothelin converting enzyme ECE1 and regulating its activity of conversion of the endothelin-1 precursor to endothelin.
Protein Name Tetraspanin-8
Tspan-8
Transmembrane 4 Superfamily Member 3
Tumor-Associated Antigen Co-029
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Tetraspanin-8 protein
Tspan-8 protein
Transmembrane 4 Superfamily Member 3 protein
Tumor-Associated Antigen Co-029 protein
TSPAN8 protein
TM4SF3 protein

Information sourced from Uniprot.org

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