Name: Human TSPAN8 protein (Recombinant) (N-GST & C-His) (STJP010880)
SKU: STJP010880
Availability: InStock

Human TSPAN8 protein (Recombinant) (N-GST & C-His) (STJP010880)

SKU:

STJP010880

£208.50 - £1,163.50

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Short Description :	Recombinant-Human TSPAN8-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications.
Applications:	ELISA/Immunogen/SDS-PAGE/WB
Host:	E.coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range:	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Function	Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking. Promotes ADAM17-mediated TNF-alpha processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration. Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR. Contributes to the maintenance of intestinal epithelial barrier and plays a role in the regulation of intestine inflammation by switching interferon gamma receptor 1/IFNGR1 from clathrin-dependent to lipid raft-dependent endocytosis route to limit STAT1 activation magnitude and duration. Acts as a modulator of the endothelin axis by associating with endothelin converting enzyme ECE1 and regulating its activity of conversion of the endothelin-1 precursor to endothelin.
Protein Name	Tetraspanin-8 Tspan-8 Transmembrane 4 Superfamily Member 3 Tumor-Associated Antigen Co-029
Database Links
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Protein Names	Tetraspanin-8 protein Tspan-8 protein Transmembrane 4 Superfamily Member 3 protein Tumor-Associated Antigen Co-029 protein TSPAN8 protein TM4SF3 protein

Information sourced from Uniprot.org

Human TSPAN8 protein (Recombinant) (N-GST & C-His) (STJP010880)

General Information

Model	Name	Host	Application
STJP011289	Human SOX9, N-GST & C-His protein (Recombinant) (N-GST & C-His) (STJP011289)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP009619	Human WAS protein (Recombinant) (N-GST & C-His) (STJP009619)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP015696	Human HOXA9 protein (Recombinant) (N-GST & C-His) (STJP015696)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP015691	Human DVL1 protein (Recombinant) (N-GST & C-His) (STJP015691)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP015688	Human HTR7 protein (Recombinant) (N-GST & C-His) (STJP015688)	E.coli	ELISA/Immunogen/SDS-PAGE/WB