| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.074ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This TSPAN1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | TSPAN1 |
| Gene ID: | 10103 |
| Uniprot ID: | TSN1_HUMAN |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways. Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Promotes also the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process. |
| Protein Name | Tetraspanin-1 Tspan-1 Tetraspan Net-1 Tetraspanin Tm4-C |
| Database Links | |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Lysosome Membrane |
| Alternative ELISA Names | Tetraspanin-1 ELISA kit Tspan-1 ELISA kit Tetraspan Net-1 ELISA kit Tetraspanin Tm4-C ELISA kit TSPAN1 ELISA kit |
| output |
Information sourced from Uniprot.org
