Human TSEN15 protein (Recombinant) (His-Tag) (STJP017207)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human TSEN15-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% Glycerol, 200mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TSEN15 |
| Gene ID | 116461 |
| Uniprot ID | SEN15_HUMAN |
| Accession Number | NP_443197 |
| Immunogen | Human |
| Immunogen Region | 1-171aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MEERGDSEPT PGCSGLGPDG VRGFGDGGGA PSWAPEDAWM GTHPKYLEMM ELDIGDATHV YVAFLVYLDL MESKSWHEVN CVGLPELQLI CLVGTEIEGE GLQTVVPTPI TASLSHNRIR EILKASRKLQ GDPDLPMSFT LAIVESDSTI VYYKLTDGFM LPDPQNISLR R |
Additional Info
| Tissue Specificity | Widely expressed. Highly expressed in testis and uterus. |
| Function | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. |
| Protein Name | Trna-Splicing Endonuclease Subunit Sen15Sen15 HomologHssen15Trna-Intron Endonuclease Sen15 |
| Database Links | Reactome: R-HSA-6784531 |
| Cellular Localisation | NucleusNucleolusMay Be Transiently Localized In The Nucleolus |
| Alternative Protein Names | Trna-Splicing Endonuclease Subunit Sen15 proteinSen15 Homolog proteinHssen15 proteinTrna-Intron Endonuclease Sen15 proteinTSEN15 proteinC1orf19 proteinSEN15 protein |
Information sourced from Uniprot.org