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Human Trk-C/NTRK3 protein (Recombinant) (C-hFc & His) (STJP002615)

Human Trk-C/NTRK3 protein (Recombinant) (C-hFc & His) (STJP002615)

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STJP002615

€174.38 - €364.38

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General Information
Product Properties
Target Information
Additional Info
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Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 1.0 EU/Mu g of the protein by LAL method.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human NTF3 at 2 Mu g/mL (100 Mu L/well) can bind Recombinant human TrkC with a linear range of 22-90 ng/mL.

Gene Symbol:	NTRK3
Gene ID:	4916
Uniprot ID:	NTRK3_HUMAN
Immunogen Region:	Cys32-Asp428
Immunogen:	Recombinant Human Trk-C/NTRK3 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Cys32-Asp428) of human TrkC/NTRK3 (Accession #NP_001012338.1) fused with an Fc, 6×His tag at the C-terminus.
Immunogen Sequence:	CPANCVCSKTEINCRRPDDG NLFPLLEGQDSGNSNGNASI NITDISRNITSIHIENWRSL HTLNAVDMELYTGLQKLTIK NSGLRSIQPRAFAKNPHLRY INLSSNRLTTLSWQLFQTLS LRELQLEQNFFNCSCDIRWM QLWQEQGEAKLNSQNLYCIN ADGSQLPLFRMNISQCDLPE ISVSHVNLTVREGDNAVITC NGSGSPLPDVDWIVTGLQSI NTHQTNLNWTNVHAINLTL

Post Translational Modifications	Ligand-mediated auto-phosphorylation.
Function	Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Protein Name	Nt-3 Growth Factor Receptor Gp145-Trkc Trk-C Neurotrophic Tyrosine Kinase Receptor Type 3 Trkc Tyrosine Kinase
Database Links	Reactome: R-HSA-1257604 Reactome: R-HSA-2219530 Reactome: R-HSA-388844 Reactome: R-HSA-6811558 Reactome: R-HSA-9034013 Reactome: R-HSA-9034015 Reactome: R-HSA-9034793 Reactome: R-HSA-9034864 Reactome: R-HSA-9603381 Reactome: R-HSA-9603505
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Nt-3 Growth Factor Receptor protein Gp145-Trkc protein Trk-C protein Neurotrophic Tyrosine Kinase Receptor Type 3 protein Trkc Tyrosine Kinase protein NTRK3 protein TRKC protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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