| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g |
| Gene Symbol: | TNFRSF10A |
| Gene ID: | 8797 |
| Uniprot ID: | TR10A_HUMAN |
| Immunogen Region: | Ala109-Asn239 |
| Immunogen: | Recombinant Human TRAIL R1/DR4/TNFRSF10A Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ala109-Asn239) of Human TRAIL R1/DR4/TNFRSF10A fused with His tag at the C-terminal. |
| Immunogen Sequence: | ATIKLHDQSIGTQQWEHSPL GELCPPGSHRSEHPGACNRC TEGVGYTNASNNLFACLPCT ACKSDEEERSPCTTTRNTAC QCKPGTFRNDNSAEMCRKCS RGCPRGMVKVKDCTPWSDIE CVHKESGNGHN |
| Post Translational Modifications | Palmitoylated. Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death. Palmitoylated by ZDHHC3 (Probable). |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10aDeath Receptor 4Tnf-Related Apoptosis-Inducing Ligand Receptor 1Trail Receptor 1Trail-R1Cd Antigen Cd261 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-202733Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6803211Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftCytoplasmCytosolPalmitoylation Is Required For Association With Membranes |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 10a proteinDeath Receptor 4 proteinTnf-Related Apoptosis-Inducing Ligand Receptor 1 proteinTrail Receptor 1 proteinTrail-R1 proteinCd Antigen Cd261 proteinTNFRSF10A proteinAPO2 proteinDR4 proteinTRAILR1 protein |
Information sourced from Uniprot.org
