Tissue Specificity | Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood. |
Post Translational Modifications | Ubiquitinated at Lys-318 by the SCF(FBXL2) complex, leading to its degradation by the proteasome. |
Function | Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. |
Protein Name | Tnf Receptor-Associated Factor 5Ring Finger Protein 84 |
Database Links | |
Cellular Localisation | CytoplasmCytosol |
Alternative ELISA Names | Tnf Receptor-Associated Factor 5 ELISA kitRing Finger Protein 84 ELISA kitTRAF5 ELISA kitRNF84 ELISA kit |
output | |
Information sourced from Uniprot.org