Human TRAF4 protein (Recombinant) (N-His) (STJP005942)

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STJP005942
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TRAF4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TRAF4
Gene ID: 9618
Uniprot ID: TRAF4_HUMAN
Immunogen Region: Gln193-Asp444
Immunogen: Homo sapiens (Human)
Post Translational Modifications Polyubiquitinated, leading to its proteasomal degradation. Ubiquitinated at Lys-263 by the SCF(FBXL2) complex, leading to its degradation by the proteasome.
Function Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway.
Protein Name Tnf Receptor-Associated Factor 4
Cysteine-Rich Domain Associated With Ring And Traf Domains Protein 1
Metastatic Lymph Node Gene 62 Protein
Mln 62
Ring Finger Protein 83
Cellular Localisation Cytoplasm
Nucleus
Perinuclear Region
Cell Junction
Tight Junction
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoskeleton
Alternative Protein Names Tnf Receptor-Associated Factor 4 protein
Cysteine-Rich Domain Associated With Ring And Traf Domains Protein 1 protein
Metastatic Lymph Node Gene 62 Protein protein
Mln 62 protein
Ring Finger Protein 83 protein
TRAF4 protein
CART1 protein
MLN62 protein
RNF83 protein

Information sourced from Uniprot.org