Human TRAF-1 protein (Recombinant) (His-Tag) (STJP016711)

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STJP016711
£125.50 - £649.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TRAF-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRAF1
Gene ID: 7185
Uniprot ID: TRAF1_HUMAN
Immunogen Region: 266-416aa
Accession Number: NP_005649
Immunogen: Human
Immunogen Sequence: MDGTFLWKIT NVTRRCHESA CGRTVSLFSP AFYTAKYGYK LCLRLYLNGD GTGKRTHLSL FIVIMRGEYD ALLPWPFRNK VTFMLLDQNN REHAIDAFRP DLSSASFQRP QSETNVASGC PLFFPLSKLQ SPKHAYVKDD TMFLKCIVET ST
Post Translational Modifications Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation. Ubiquitinated by the SCF(FBXL2) complex, leading to its degradation by the proteasome.
Function Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
Protein Name Tnf Receptor-Associated Factor 1
Epstein-Barr Virus-Induced Protein 6
Database Links Reactome: R-HSA-5357905
Reactome: R-HSA-5357956
Cellular Localisation
Alternative Protein Names Tnf Receptor-Associated Factor 1 protein
Epstein-Barr Virus-Induced Protein 6 protein
TRAF1 protein
EBI6 protein

Information sourced from Uniprot.org

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