Human TPM2 protein (Recombinant) (His-Tag) (STJP017011)

Name: Human TPM2 protein (Recombinant) (His-Tag) (STJP017011)
SKU: STJP017011
Availability: InStock

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SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017011

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Short Description	Recombinant-Human TPM2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.25 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 30% Glycerol, 100mM NaCl
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	TPM2
Gene ID	7169
Uniprot ID	TPM2_HUMAN
Accession Number	NP_998839.1
Immunogen	Human
Immunogen Region	1-284aa
Immunogen Sequence	MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE AKHIAEDSDR KYEEVARKLV ILEGELERSE ERAEVAESRA RQLEEELRTM DQALKS

Tissue Specificity	Present in primary breast cancer tissue, absent from normal breast tissue.
Post Translational Modifications	Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization.
Function	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
Protein Name	Tropomyosin Beta Chain Beta-Tropomyosin Tropomyosin-2
Database Links	Reactome: R-HSA-390522 Reactome: R-HSA-445355
Cellular Localisation	Cytoplasm Cytoskeleton Associates With F-Actin Stress Fibers
Alternative Protein Names	Tropomyosin Beta Chain protein Beta-Tropomyosin protein Tropomyosin-2 protein TPM2 protein TMSB protein

Information sourced from Uniprot.org