| Post Translational Modifications | In vitro phosphorylated by CHUK. Ubiquitinated.undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination. Deubiquitinated by USP35.leading to stabilization and inhibition of TNFalpha-induced NF-kappa-B activation. |
| Function | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response.this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells.promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. |
| Protein Name | Tnfaip3-Interacting Protein 2A20-Binding Inhibitor Of Nf-Kappa-B Activation 2Abin-2Fetal Liver Lkb1-Interacting Protein |
| Database Links | Reactome: R-HSA-5684264Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Tnfaip3-Interacting Protein 2 proteinA20-Binding Inhibitor Of Nf-Kappa-B Activation 2 proteinAbin-2 proteinFetal Liver Lkb1-Interacting Protein proteinTNIP2 proteinABIN2 proteinFLIP1 protein |
Information sourced from Uniprot.org
