Human TNIP2 protein (Recombinant) (N-His) (STJP005730)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TNIP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TNIP2 |
| Gene ID | 79155 |
| Uniprot ID | TNIP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu31-Glu184 |
Additional Info
| Post Translational Modifications | In vitro phosphorylated by CHUK. Ubiquitinated.undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination. Deubiquitinated by USP35.leading to stabilization and inhibition of TNFalpha-induced NF-kappa-B activation. |
| Function | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response.this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells.promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. |
| Protein Name | Tnfaip3-Interacting Protein 2A20-Binding Inhibitor Of Nf-Kappa-B Activation 2Abin-2Fetal Liver Lkb1-Interacting Protein |
| Database Links | Reactome: R-HSA-5684264Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Tnfaip3-Interacting Protein 2 proteinA20-Binding Inhibitor Of Nf-Kappa-B Activation 2 proteinAbin-2 proteinFetal Liver Lkb1-Interacting Protein proteinTNIP2 proteinABIN2 proteinFLIP1 protein |
Information sourced from Uniprot.org