| Tissue Specificity | Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells. |
| Post Translational Modifications | Phosphorylation at Tyr-552 by SRC-family kinases recruits phosphoinositide-3-kinase (PI3K) PIK3CD:p85 heterodimer which results in integrin activation and leukocyte adhesion to activated endothelium during inflammation. |
| Function | Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG.proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway.blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity.this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation.this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. |
| Protein Name | Tnfaip3-Interacting Protein 1A20-Binding Inhibitor Of Nf-Kappa-B Activation 1Abin-1Hiv-1 Nef-Interacting ProteinNef-Associated Factor 1Naf1Nip40-1Virion-Associated Nuclear Shuttling ProteinVanHvan |
| Database Links | Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Nucleus And Cytoplasm In A Crm1-Dependent Manner |
| Alternative Protein Names | Tnfaip3-Interacting Protein 1 proteinA20-Binding Inhibitor Of Nf-Kappa-B Activation 1 proteinAbin-1 proteinHiv-1 Nef-Interacting Protein proteinNef-Associated Factor 1 proteinNaf1 proteinNip40-1 proteinVirion-Associated Nuclear Shuttling Protein proteinVan proteinHvan proteinTNIP1 proteinKIAA0113 proteinNAF1 protein |
Information sourced from Uniprot.org
