| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1.0 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CD70 |
| Gene ID: | 970 |
| Uniprot ID: | CD70_HUMAN |
| Immunogen Region: | Gln39-Pro193 |
| Immunogen: | Recombinant Human TNFSF7/CD27 Ligand/CD70 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln39-Pro193) of human CD70 (Accession #NP_001243.1) fused with an Fc tag at the N-terminus. |
| Immunogen Sequence: | GDQNPQIAAHVISEASSKTT SVLQWAEKGYYTMSNNLVTL ENGKQLTVKRQGLYYIYAQV TFCSNREASSQAPFIASLCL KSPGRFERILLRAANTHSSA KPCGQQSIHLGGVFELQPGA SVFVNVTDPSQVSHGTGFTS FGLLKL |
| Post Translational Modifications | N-glycosylated. |
| Function | Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. |
| Protein Name | Cd70 AntigenCd27 LigandCd27-LTumor Necrosis Factor Ligand Superfamily Member 7Cd Antigen Cd70 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Cd70 Antigen proteinCd27 Ligand proteinCd27-L proteinTumor Necrosis Factor Ligand Superfamily Member 7 proteinCd Antigen Cd70 proteinCD70 proteinCD27L proteinCD27LG proteinTNFSF7 protein |
Information sourced from Uniprot.org