Human TNFSF18/GITR Ligand Trimer protein (Recombinant) (N-His&Flag) {Biotin} (STJP020245)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human GITR Ligand/TNFSF18 Trimer Protein (Primary Amine Labeling) is expressed from Expi293 with His tag and flag tag at the N-terminal.οΌIt contains Gln50-Ser177.
General Information
| Short Description | Recombinant-Human TNFSF18/GITR Ligand Trimer-N-His&Flag protein was developed in hek293 cells using the region NA. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | TNFSF18 |
| Gene ID | 8995 |
| Uniprot ID | TNF18_HUMAN |
| Immunogen | Biotinylated Recombinant Human GITR Ligand/TNFSF18 Trimer Protein (Primary Amine Labeling) is expressed from Expi293 with His tag and flag tag at the N-terminal.οΌIt contains Gln50-Ser177. |
Additional Info
| Tissue Specificity | Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. |
| Function | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 18Activation-Inducible Tnf-Related LigandAitrlGlucocorticoid-Induced Tnf-Related LigandHgitrl |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 18 proteinActivation-Inducible Tnf-Related Ligand proteinAitrl proteinGlucocorticoid-Induced Tnf-Related Ligand proteinHgitrl proteinTNFSF18 proteinAITRL proteinGITRL proteinTL6 proteinUNQ149 proteinPRO175 protein |
Information sourced from Uniprot.org