| Tissue Specificity | Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. |
| Function | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 18Activation-Inducible Tnf-Related LigandAitrlGlucocorticoid-Induced Tnf-Related LigandHgitrl |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 18 proteinActivation-Inducible Tnf-Related Ligand proteinAitrl proteinGlucocorticoid-Induced Tnf-Related Ligand proteinHgitrl proteinTNFSF18 proteinAITRL proteinGITRL proteinTL6 proteinUNQ149 proteinPRO175 protein |
Information sourced from Uniprot.org
