Post Translational Modifications | N-glycosylated. The soluble form of isoform 1 derives from the membrane form by proteolytic processing. |
Function | Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production. |
Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 14Herpes Virus Entry Mediator LigandHvem-LHerpesvirus Entry Mediator LigandCd Antigen Cd258 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 14 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 14 - Soluble Form |
Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-5676594 |
Cellular Localisation | Tumor Necrosis Factor Ligand Superfamily Member 14Membrane Form: Cell MembraneSingle-Pass Type Ii Membrane ProteinSoluble Form: SecretedIsoform 2: Cytoplasm |
Alternative Antibody Pair Names | Tumor Necrosis Factor Ligand Superfamily Member 14 antibody pairHerpes Virus Entry Mediator Ligand antibody pairHvem-L antibody pairHerpesvirus Entry Mediator Ligand antibody pairCd Antigen Cd258 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 14 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 14 - Soluble Form antibody pairTNFSF14 antibody pairHVEML antibody pairLIGHT antibody pairUNQ391 antibody pairPRO726 antibody pair |
Information sourced from Uniprot.org