| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
Please contact us for more information. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF14 at 2 Mu g/mL (100 Mu L/well) can bind Mouse HVEM with a linear range of 0.02-0.89 Mu g/mL. |
| Gene Symbol: |
TNFSF14 |
| Gene ID: |
8740 |
| Uniprot ID: |
TNF14_HUMAN |
| Immunogen: |
Recombinant Human TNFSF14/LIGHT/HVEM-L/CD258 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp74-Val240) of Human TNFSF14 (Accession #NP_003798.2) fused with a 6×His tag at the N-terminus. |
| Immunogen Sequence: |
DGPAGSWEQLIQERRSHEVN PAAHLTGANSSLTGSGGPLL WETQLGLAFLRGLSYHDGAL VVTKAGYYYIYSKVQLGGV GCPLGLASTITHGLYKRTPR YPEELELLVSQQSPCGRATS S SRVWWDSSFLGGVVHLEA GEKVVVRVLDERLVRLRDGT RSYFGAFMV |
| Post Translational Modifications | N-glycosylated. The soluble form of isoform 1 derives from the membrane form by proteolytic processing. |
| Function | Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 14Herpes Virus Entry Mediator LigandHvem-LHerpesvirus Entry Mediator LigandCd Antigen Cd258 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 14 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 14 - Soluble Form |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-5676594 |
| Cellular Localisation | Tumor Necrosis Factor Ligand Superfamily Member 14Membrane Form: Cell MembraneSingle-Pass Type Ii Membrane ProteinSoluble Form: SecretedIsoform 2: Cytoplasm |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 14 proteinHerpes Virus Entry Mediator Ligand proteinHvem-L proteinHerpesvirus Entry Mediator Ligand proteinCd Antigen Cd258 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 14 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 14 - Soluble Form proteinTNFSF14 proteinHVEML proteinLIGHT proteinUNQ391 proteinPRO726 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
