Name: Human TNFSF12/TWEAK protein (Recombinant) (No tag) (STJP001438)
SKU: STJP001438
Availability: InStock

Human TNFSF12/TWEAK protein (Recombinant) (No tag) (STJP001438)

SKU:

STJP001438

$144.21 - $479.55

Host:	E.coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation:	Unconjugated
Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	<0.1 EU/Mu g
Immunoreactivity:	1.Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF12 at 2 Mu g/mL (100 Mu L/well) can bind Human TNFRSF12A with a linear range of 0.1-2.3 ng/mL.\|2.Measured in a cell proliferation assay using human umbilical vein endothe

Gene Symbol:	TNFSF12
Gene ID:	8742
Uniprot ID:	TNF12_HUMAN
Immunogen Region:	Lys97-His249
Immunogen:	Recombinant Human TNFSF12/TWEAK Protein is produced by E. coli expression system. The target protein is expressed with sequence (Lys97-His249 ( N-Met) ) of human TWEAK/TNFSF12 (Accession #NP_003800.1) fused with no additional amino acid.
Immunogen Sequence:	KGRKTRARRAIAAHYEVHPR PGQDGAQAGVDGTVSGWEEA RINSSSPLRYNRQIGEFIVT RAGLYYLYCQVHFDEGKAVY LKLDLLVDGVLALRCLEEFS ATAASSLGPQLRLCQVSGLL ALRPGSSLRIRTLPWAHLKA APFLTYFGLFQVH

Post Translational Modifications	The soluble form derives from the membrane form by proteolytic processing.
Function	Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
Protein Name	Tumor Necrosis Factor Ligand Superfamily Member 12 Apo3 Ligand Tnf-Related Weak Inducer Of Apoptosis Tweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form
Database Links	Reactome: R-HSA-5668541 Reactome: R-HSA-5676594
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Tumor Necrosis Factor Ligand Superfamily Member 12 Secreted Form: Secreted Isoform Twe-Pril: Cell Membrane Single-Pass Membrane Protein
Alternative Protein Names	Tumor Necrosis Factor Ligand Superfamily Member 12 protein Apo3 Ligand protein Tnf-Related Weak Inducer Of Apoptosis protein Tweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form protein TNFSF12 protein APO3L protein DR3LG protein UNQ181 protein PRO207 protein

Information sourced from Uniprot.org

Model	Name	Host	Clonality	Reactivity	Application
STJP009519	Human TNFSF12/APO3L/TWEAK protein (Recombinant) (C-His) (STJP009519)	Mammalian Cells
STJP003278	Human TNFSF12 protein (Recombinant) (N-His) (STJP003278)	E. coli
STJA0020253	Anti-TNFSF12/APO3L/TWEAK antibody [SAA1825] (STJA0020253)	Mouse	Monoclonal	Human	ELISA
STJAP00409	Human TWEAK (TWEAK) Antibody Pair (STJAP00409)	Goat/Goat		Human	ELISA
STJP003015	Human DNMT1 protein (Recombinant) (No tag) (STJP003015)	E.coli

Human TNFSF12/TWEAK protein (Recombinant) (No tag) (STJP001438)

General Information