| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Immunoreactivity: | Immobilized Human TNFSF10 Protein at 5 Mu g/mL (100 Mu L/well) can bind HumanTNFRSF11B with a linear range of 0.0012-107.86 ng/mL. |
| Gene Symbol: | TNFSF10 |
| Gene ID: | 8743 |
| Uniprot ID: | TNF10_HUMAN |
| Immunogen Region: | Val114-Gly281 |
| Immunogen: | Recombinant Human TNFSF10/TRAIL/CD253 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Val114-Gly281) of human TNFSF10/TRAIL/CD253 (Accession #NP_003801.1) fused with no additional amino acid. |
| Immunogen Sequence: | IWELKKDVYVVELDWYPDAP GEMVVLTCDTPEEDGITWTL DQSSEVLGSGKTLTIQVKEF GDAGQYTCHKGGEVLSHSLL LLHKKEDGIWSTDILKDQKE PKNKTFLRCEAKNYSGRFTC WWLTTISTDLTFSVKSSRGS SDPQGVTCGAATLSAERVRG DNKEYEYSVECQEDSACPAA EESLPIEVMVDAVHKLKYEN YTSSFFIRDIIKPDPPKNLQ LKPLKNSRQVEVSWEYPDT |
| Tissue Specificity | Widespread.most predominant in spleen, lung and prostate. |
| Post Translational Modifications | Tyrosine phosphorylated by PKDCC/VLK. |
| Function | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 10Apo-2 LigandApo-2lTnf-Related Apoptosis-Inducing LigandProtein TrailCd Antigen Cd253 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinSecretedExists Both As Membrane-Bound And Soluble Form |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 10 proteinApo-2 Ligand proteinApo-2l proteinTnf-Related Apoptosis-Inducing Ligand proteinProtein Trail proteinCd Antigen Cd253 proteinTNFSF10 proteinAPO2L proteinTRAIL protein |
Information sourced from Uniprot.org