| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF9 at 2 Mu g/mL (100 Mu L/well) can bind Human TNFRSF9 with a linear range of 0.1-12.9 ng/mL. |
| Gene Symbol: | TNFRSF9 |
| Gene ID: | 3604 |
| Uniprot ID: | TNR9_HUMAN |
| Immunogen Region: | Leu 24-Gln 186 |
| Immunogen: | Recombinant Human TNFRSF9/4-1BB/CD137 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu 24-Gln 186) of human 4-1BB/CD137 (Accession #NP_001552) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: | LQDPCSNCPAGTFCDNNRNQ ICSPCPPNSFSSAGGQRTCD ICRQCKGVFRTRKECSSTSN AECDCTPGFHCLGAGCSMCE QDCKQGQELTKKGCKDCCFG TFNDQKRGICRPWTNCSLDG KSVLVNGTKERDVVCGPSPA DLSPGASSVTPPAPAREPGH SPQ |
| Function | Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable). |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 94-1bb Ligand ReceptorCdw137T-Cell Antigen 4-1bb HomologT-Cell Antigen IlaCd Antigen Cd137 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 9 protein4-1bb Ligand Receptor proteinCdw137 proteinT-Cell Antigen 4-1bb Homolog proteinT-Cell Antigen Ila proteinCd Antigen Cd137 proteinTNFRSF9 proteinCD137 proteinILA protein |
Information sourced from Uniprot.org