| Host: | Mammalian Cells |
| Applications: | ELISA/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Human TNFRSF6B/DcR3-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its ability to inhibit Fas Ligandinduced apoptosis of human acute T cell leukemia cells (Jurkat). The ED50 for this effect is 0.03-0.15 µg/mL in the presence of 20 ng/mL rhFas Ligand. |
| Gene Symbol: | TNFRSF6B |
| Gene ID: | 8771 |
| Uniprot ID: | TNF6B_HUMAN |
| Immunogen Region: | Val24-His300 |
| Immunogen: | Homo sapiens (Human) |
| Function | Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 6bDecoy Receptor 3Dcr3Decoy Receptor For Fas LigandM68 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 6b proteinDecoy Receptor 3 proteinDcr3 proteinDecoy Receptor For Fas Ligand proteinM68 proteinTNFRSF6B proteinDCR3 proteinTR6 proteinUNQ186 proteinPRO212 protein |
Information sourced from Uniprot.org