| Host: | Mouse/Goat |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | This TNFRSF1A antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Clonality: | Monoclonal/Polyclonal |
| Conjugation: | Unconjugated/Biotin |
| Formulation: | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Purification: | Capture Purification: Protein A or G. Detection Purification: Antigen Affinity. |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | TNFRSF1A |
| Gene ID: | 7132 |
| Uniprot ID: | TNR1A_HUMAN |
| Immunogen: | Capture immunogen: Recombinant Human TNFRSF1A protein. Detection Immunogen: Recombinant Human TNFRSF1A protein. |
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1a Tumor Necrosis Factor Receptor 1 Tnf-R1 Tumor Necrosis Factor Receptor Type I Tnf-Ri Tnfr-I P55 P60 Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 Tbpi |
| Database Links | Reactome: R-HSA-5357786 Reactome: R-HSA-5357905 Reactome: R-HSA-5357956 Reactome: R-HSA-5626978 Reactome: R-HSA-5669034 Reactome: R-HSA-6783783 Reactome: R-HSA-75893 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Golgi Apparatus Membrane Secreted A Secreted Form Is Produced Through Proteolytic Processing Isoform 4: Secreted Lacks A Golgi-Retention Motif Is Not Membrane Bound And Therefore Is Secreted |
| Alternative Antibody Pair Names | Tumor Necrosis Factor Receptor Superfamily Member 1a antibody pair Tumor Necrosis Factor Receptor 1 antibody pair Tnf-R1 antibody pair Tumor Necrosis Factor Receptor Type I antibody pair Tnf-Ri antibody pair Tnfr-I antibody pair P55 antibody pair P60 antibody pair Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 antibody pair Tbpi antibody pair TNFRSF1A antibody pair TNFAR antibody pair TNFR1 antibody pair |
Information sourced from Uniprot.org
