| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
1.Measured by its binding ability in a functional ELISA.Immobilized Human TNFRSF1A at 2 Mu g/mL (100 Mu L/well) can bind Mouse TNF Alpha with a linear range of 4-135 ng/mL.|2.Measured by its ability to inhibit TNF Alpha-mediated cytotoxicity in the L |
| Gene Symbol: |
TNFRSF1A |
| Gene ID: |
7132 |
| Uniprot ID: |
TNR1A_HUMAN |
| Immunogen: |
Recombinant Human TNFRSF1A/TNF-R1/CD120a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile22-Thr211) of human CD120a/TNFRSF1A (Accession #NP_001056.1) fused with 6×His tag at the C-terminus. |
| Immunogen Sequence: |
IYPSGVIGLVPHLGDREKRD SVCPQGKYIHPQNNSICCTK CHKGTYLYNDCPGPGQDTDC RECESGSFTASENHLRHCL SCSKCRKEMGQVEISSCTVD RDTVCGCRKNQYRHYWSENL F QCFNCSLCLNGTVHLSCQ EKQNTVCTCHAGFFLRENEC VSCSNCKKSLECTKLCLPQI EN VKGTEDSGTT |
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1aTumor Necrosis Factor Receptor 1Tnf-R1Tumor Necrosis Factor Receptor Type ITnf-RiTnfr-IP55P60Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1Tbpi |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5626978Reactome: R-HSA-5669034Reactome: R-HSA-6783783Reactome: R-HSA-75893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi Apparatus MembraneSecretedA Secreted Form Is Produced Through Proteolytic ProcessingIsoform 4: SecretedLacks A Golgi-Retention MotifIs Not Membrane Bound And Therefore Is Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 1a proteinTumor Necrosis Factor Receptor 1 proteinTnf-R1 proteinTumor Necrosis Factor Receptor Type I proteinTnf-Ri proteinTnfr-I proteinP55 proteinP60 proteinCd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 proteinTbpi proteinTNFRSF1A proteinTNFAR proteinTNFR1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
