Name: Human TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-His) (STJP001338)
SKU: STJP001338
Availability: InStock

Human TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-His) (STJP001338)

SKU:

STJP001338

£80.50 - £257.50

General Information
Product Properties
Target Information
Additional Info
Product Review

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 1 EU/Mu g of the protein by LAL method.
Immunoreactivity:	1.Measured by its binding ability in a functional ELISA.Immobilized Human TNFRSF1A at 2 Mu g/mL (100 Mu L/well) can bind Mouse TNF Alpha with a linear range of 4-135 ng/mL.\|2.Measured by its ability to inhibit TNF Alpha-mediated cytotoxicity in the L

Gene Symbol:	TNFRSF1A
Gene ID:	7132
Uniprot ID:	TNR1A_HUMAN
Immunogen:	Recombinant Human TNFRSF1A/TNF-R1/CD120a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile22-Thr211) of human CD120a/TNFRSF1A (Accession #NP_001056.1) fused with 6×His tag at the C-terminus.
Immunogen Sequence:	IYPSGVIGLVPHLGDREKRD SVCPQGKYIHPQNNSICCTK CHKGTYLYNDCPGPGQDTDC RECESGSFTASENHLRHCL SCSKCRKEMGQVEISSCTVD RDTVCGCRKNQYRHYWSENL F QCFNCSLCLNGTVHLSCQ EKQNTVCTCHAGFFLRENEC VSCSNCKKSLECTKLCLPQI EN VKGTEDSGTT

Function	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Protein Name	Tumor Necrosis Factor Receptor Superfamily Member 1a Tumor Necrosis Factor Receptor 1 Tnf-R1 Tumor Necrosis Factor Receptor Type I Tnf-Ri Tnfr-I P55 P60 Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 Tbpi
Database Links	Reactome: R-HSA-5357786 Reactome: R-HSA-5357905 Reactome: R-HSA-5357956 Reactome: R-HSA-5626978 Reactome: R-HSA-5669034 Reactome: R-HSA-6783783 Reactome: R-HSA-75893
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Golgi Apparatus Membrane Secreted A Secreted Form Is Produced Through Proteolytic Processing Isoform 4: Secreted Lacks A Golgi-Retention Motif Is Not Membrane Bound And Therefore Is Secreted
Alternative Protein Names	Tumor Necrosis Factor Receptor Superfamily Member 1a protein Tumor Necrosis Factor Receptor 1 protein Tnf-R1 protein Tumor Necrosis Factor Receptor Type I protein Tnf-Ri protein Tnfr-I protein P55 protein P60 protein Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 protein Tbpi protein TNFRSF1A protein TNFAR protein TNFR1 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP002695	Mouse TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-His) (STJP002695)	HEK293 cells
STJP001404	Human TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-hFc) (STJP001404)	HEK293 cells
STJP002696	Mouse TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-hFc & His) (STJP002696)	HEK293 cells
STJP002037	Human TRAIL-R1/CD261 protein (Recombinant) (C-His) (STJP002037)	HEK293 cells
STJP001093	Human TNF-alpha protein (Active Recombinant) (C-His) (STJP001093)	HEK293 cells
STJP002598	Human IFN-gamma R1/CD119 protein (Recombinant) (C-His) (STJP002598)	HEK293 cells
STJP001021	Human TNFRSF1B/TNF-R2/CD120b protein (Recombinant) (C-His) (STJP001021)	HEK293 cells

Human TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-His) (STJP001338)

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