| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | 1.Measured by its ability to inhibit TWEAK-induced apoptosis in HT-29 human colon adenocarcinoma cells. The ED50 for this effect is 2-12 Mu g/mL in the presence of 1 Mu g/mL recombinant human TWEAK.|2.Measured by its binding ability in a f |
| Gene Symbol: | TNFRSF12A |
| Gene ID: | 51330 |
| Uniprot ID: | TNR12_HUMAN |
| Immunogen Region: | Glu28-Trp79 |
| Immunogen: | Recombinant Human TNFRSF12A/TWEAKR/CD266 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Glu28-Trp79) of human TNFRSF12A/FN14/TWEAKR (Accession #NP_057723.1) fused with an Fc, 6×His tag at the C-terminu |
| Immunogen Sequence: | EQAPGTAPCSRGSSWSADLD KCMDCASCRARPHSDFCLGC AAAPPAPFRLLW |
| Function | Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 12aFibroblast Growth Factor-Inducible Immediate-Early Response Protein 14Fgf-Inducible 14Tweak-ReceptorTweakrCd Antigen Cd266 |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5676594 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 12a proteinFibroblast Growth Factor-Inducible Immediate-Early Response Protein 14 proteinFgf-Inducible 14 proteinTweak-Receptor proteinTweakr proteinCd Antigen Cd266 proteinTNFRSF12A proteinFN14 protein |
Information sourced from Uniprot.org
