Human TNFRSF11B protein (Recombinant) (N-His) (STJP003142)

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STJP003142
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TNFRSF11B-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TNFRSF11B
Gene ID: 4982
Uniprot ID: TR11B_HUMAN
Immunogen Region: Thr76-Lys317
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. Contains sialic acid residues. The N-terminus is blocked.
Function Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 11b
Osteoclastogenesis Inhibitory Factor
Osteoprotegerin
Database Links Reactome: R-HSA-5669034
Cellular Localisation Secreted
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 11b protein
Osteoclastogenesis Inhibitory Factor protein
Osteoprotegerin protein
TNFRSF11B protein
OCIF protein
OPG protein

Information sourced from Uniprot.org

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