| Short Description : | Recombinant-Human TNF-beta-C-6His protein was developed in cho cells using the region Leu35-Leu205. For use in research applications. |
| Host: | CHO Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method |
| Gene Symbol: | LTA |
| Gene ID: | 4049 |
| Uniprot ID: | TNFB_HUMAN |
| Immunogen: | Recombinant Human TNF-beta Protein is produced by CHO Cells expression system. The target protein is expressed with sequence (Leu35-Leu205) of Human TNF-beta (Accession #NP_000586.2) fused with His at the C-terminus.. |
| Immunogen Region: | Leu35-Leu205 |
| Immunogen Sequence: | LPGVGLTPSAAQTARQHPKM HLAHSTLKPAAHLIGDPSKQ NSLLWRANTDRAFLQDGFSL SNNSLLVPTSGIYFVYSQVV FSGKAYSPKATSSPLYLAHE VQLFSSQYPFHVPLLSSQKM VYPGLQEPWLHSMYHGAAFQ LTQGDQLSTHTDGIPHLVLS PSTVFFGAFAL |
| Function | Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. |
| Protein Name | Lymphotoxin-AlphaLt-AlphaTnf-BetaTumor Necrosis Factor Ligand Superfamily Member 1 |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-5676594 |
| Cellular Localisation | SecretedMembraneThe Homotrimer Is SecretedThe Heterotrimer Is Membrane-Associated |
| Alternative Protein Names | Lymphotoxin-Alpha proteinLt-Alpha proteinTnf-Beta proteinTumor Necrosis Factor Ligand Superfamily Member 1 proteinLTA proteinTNFB proteinTNFSF1 protein |
Information sourced from Uniprot.org
