Human TMEM165 protein (Recombinant) (N-GST & C-His) (STJP008818)

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STJP008818
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TMEM165-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TMEM165
Gene ID: 55858
Uniprot ID: TM165_HUMAN
Immunogen Region: Gly34-Thr89
Immunogen: Homo sapiens (Human)
Function Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway. Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk. The transport mechanism and stoichiometry remains to be elucidated.
Protein Name Putative Divalent Cation/Proton Antiporter Tmem165
Transmembrane Protein 165
Transmembrane Protein Pt27
Transmembrane Protein Tparl
Cellular Localisation Golgi Apparatus Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Putative Divalent Cation/Proton Antiporter Tmem165 protein
Transmembrane Protein 165 protein
Transmembrane Protein Pt27 protein
Transmembrane Protein Tparl protein
TMEM165 protein
TPARL protein

Information sourced from Uniprot.org

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