Human TMEFF2 protein (Recombinant) (N-His) (STJP006171)

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STJP006171
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TMEFF2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TMEFF2
Gene ID: 23671
Uniprot ID: TEFF2_HUMAN
Immunogen Region: Thr52-Arg290
Immunogen: Homo sapiens (Human)
Post Translational Modifications O-glycosylated.contains chondroitin sulfate glycosaminoglycans. A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
Function May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
Protein Name Tomoregulin-2
Tr-2
Hyperplastic Polyposis Protein 1
Transmembrane Protein With Egf-Like And Two Follistatin-Like Domains
Cellular Localisation Isoform 1: Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Membrane
Isoform 3: Secreted
Alternative Protein Names Tomoregulin-2 protein
Tr-2 protein
Hyperplastic Polyposis Protein 1 protein
Transmembrane Protein With Egf-Like And Two Follistatin-Like Domains protein
TMEFF2 protein
HPP1 protein
TENB2 protein
TPEF protein
UNQ178 protein
PRO204 protein

Information sourced from Uniprot.org

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