| Function | Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression. |
| Protein Name | Transmembrane 4 L6 Family Member 5Tetraspan Transmembrane Protein L6h |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinCell MembraneLocalization To Cell Membrane Increases During Conditions Of Arginine Depletion And Translocation To Lysosome Membrane Seen Upon Arginine Repletion |
| Alternative Protein Names | Transmembrane 4 L6 Family Member 5 proteinTetraspan Transmembrane Protein L6h proteinTM4SF5 protein |
Information sourced from Uniprot.org
