Human TLE3 protein (Recombinant) (N-His) (STJP007454)

SKU:
STJP007454
$443.48 - $1,940.63
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TLE3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TLE3
Gene ID: 7090
Uniprot ID: TLE3_HUMAN
Immunogen Region: Ser449-Tyr772
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. Ubiquitinated at Lys-720 by UBR5 in response to Wnt signaling, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome.
Function Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.
Protein Name Transducin-Like Enhancer Protein 3
Enhancer Of Split Groucho-Like Protein 3
Esg3
Database Links Reactome: R-HSA-201722
Reactome: R-HSA-2122947 Q04726-3
Reactome: R-HSA-3769402
Reactome: R-HSA-4641265
Reactome: R-HSA-9018519
Cellular Localisation Nucleus
Alternative Protein Names Transducin-Like Enhancer Protein 3 protein
Enhancer Of Split Groucho-Like Protein 3 protein
Esg3 protein
TLE3 protein
KIAA1547 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP005172 Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172) E. coli
STJP004723 Human WAS protein (Recombinant) (N-His) (STJP004723) E. coli
STJP005235 Human DSC1 protein (Recombinant) (N-His) (STJP005235) E. coli
STJP009286 Human TMPRSS2 protein (Recombinant) (N-His) (STJP009286) E. coli
STJP009313 Human TDO2 protein (Recombinant) (N-His) (STJP009313) E. coli

Related Products

!