| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
COMP |
| Gene ID: |
1311 |
| Uniprot ID: |
COMP_HUMAN |
| Immunogen: |
Recombinant Human Thrombospondin-5/COMP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln 21-Ala 757 ) of human COMP (Accession #NP_000086.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
QGQSPLGSDLGPQMLRELQE TNAALQDVRELLRQQVREIT FLKNTVMECDACGMQQSVRT GLPSVRPLLHCAPGFCFPGV ACIQTESGARCGPCPAGFTG NGSHCTDVNECNAHPCFPRV RCINTSPGFRCEACPPGYSG PTHQGVGLAFAKANKQVCTD INECETGQHNCVPNSVCINT RGSFQCGPCQPGFVGDQASG CQRRAQRFCPDGSPSECHEH ADCVLERDGSRSCVCAVGW |
| Function | Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7. |
| Protein Name | Cartilage Oligomeric Matrix ProteinCompThrombospondin-5Tsp5 |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000178 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Cartilage Oligomeric Matrix Protein proteinComp proteinThrombospondin-5 proteinTsp5 proteinCOMP protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
